These Products are useful in removing the metabolites created by use of this drug from your body for a specific period of time. and could be used to help detoxify the body in a shorter period of time that might happen should the body be let to detoxify naturally.  ATC does not condone the use of these products for any purposes that can be illegal in certain areas such as reducing the chance of failing a drug test.

Hydrocodone or dihydrocodeinone is a semi-synthetic opioid derived from two of the naturally occurring opiates codeine and thebaine. Hydrocodone is an orally active narcotic analgesic and antitussive. It is commonly available in tablet, capsule, and syrup form, and is often compounded with other analgesics like paracetamol or ibuprofen. It is marketed, in its varying forms, under a number of trademarks, including Vicodin, Symtan, Anexsia, Dicodid, Hycodan (or generically Hydromet), Hycomine, Hycet, Lorcet, Lortab, Norco, Novahistex, Hydrovo, Duodin, Kolikodol, Orthoxycol, Mercodinone, Synkonin, Norgan, and Hydrokon. Hydrocodone was first synthesized in Germany in 1920[1] and was approved by the Food and Drug Administration on 23 March 1943 for sale in the United States under the brand name Hycodan.[2][3]

The particular niche in which hydrocodone is most commonly used is as an intermediate-strength centrally acting analgesic and strong cough suppressant, especially in those for whom histamine release and attendant itching from codeine is a problem. For the latter indication, at the 5- to 10-mg dose range, hydrocodone is more powerful than most cough suppressants, being roughly equal to its derivative Dihydrocodeinone enol acetate, with the top of the list being hydromorphone (Dilaudid Cough Syrup) and methadone (Methadone linctus, about 33 percent the concentration of the liquid used for opioid physical dependence maintenance or detoxification) and dihydrocodeine being right below, as is morphine. The experiments in dogs conducted by Winder and Rosière in the mid-1950s reported in the Journal of Pharmacology in 1955 indicate that hydrocodone is 12 times stronger than codeine as an antitussive (morphine 14x, methadone 9x), and other tests from 1920 forward showed it was about six times stronger as an analgesic.

Hydromorphone, a more common synonym for dihydromorphinone and dimorphone, commonly a hydrochloride (trade names Palladone, Palladone SR, Dilaudid and numerous others) is a potent centrally-acting analgesic drug of the opioid class; it is a derivative of morphine, specifically a hydrogenated ketone thereof—therefore a semi-synthetic drug and both an opiate and a true narcotic. It should not be confused with hydromorphinol, also known as 14-hydroxydihydromorphine and RAM-320 nor dihydromorphine (Paramorfan). While all of these are strong opioids, they are indeed different drugs. Additional confusion here comes from the fact that in a handful of countries hydromorphinol is distributed under the trade name Numorphan, which is the trade name for oxymorphone in the rest of the world according to the current version of The A-Z Encyclopaedia of Alcohol & Drug Abuse and other references.

As explored below, hydromorphone is made from morphine via catalytic hydrogenation and is also produced in trace amounts by human and other mammalian metabolism of morphine and occasionally appears in assays of opium latex in very small quantities, apparently forming in the plant in an unknown percentage of cases under poorly-understood conditions.

Hydromorphone is used in medicine as an alternative to morphine and diacetylmorphine for analgesia and as a second- or third-line narcotic antitussive (cough suppressant) for cases of dry, painful, paroxysmal coughing resulting from continuing bronchial irritation after influenza and other ailments, inhalation of fungus and other causes, and is generally regarded to be the strongest of the latter class of drugs, and was developed shortly after another powerful antitussive, heroin, was removed from clinical use for this purpose in most of the world and in many countries banned outright. Part of the effectiveness of hydrocodone for this purpose may be due to part of the dose being converted to hydromorphone in the liver.

Uses
Hydromorphone is used to relieve moderate to severe pain and severe, painful dry coughing. As explored in detail below, hydromorphone is becoming more popular in the treatment of chronic pain in many countries, and it is used as a substitute for heroin and morphine where one or both of these drugs are not marketed. Hydromorphone is preferred even over morphine in many cases ranging from the emergency department to the operating suite to ongoing treatment of chronic pain syndromes on account of hydromorphone's superior solubility and speed of onset and less troublesome side effect profile and lower dependence liability as compared to morphine and heroin. Hydromorphone is thought to be 2-4 times stronger than morphine, but with a lower dependence liability. However other studies have suggested hydromorphone is less than twice as potent as hydrocodone or oxycodone and therefore just over twice as strong as morphine via oral administration.[3]

Hydromorphone's side effect profile is closer to that of dihydromorphine than that of morphine or heroin and importantly produces less nausea and vomiting and fewer histamine-related side effects (itching, redness of skin, &c.) than morphine as a result. In cases where significant doses are anticipated, hydromorphone may be easier to titrate to the needed dose for this and other related reasons. Like all other opioid analgesics, tolerance develops with repeated administration and there is no true maximum dose, although requirements for pain relief can often remain more or less constant for extended periods after initial titration and tolerance does indeed commonly follow a course of plateaus of this type interspersed with comparatively infrequent escalations of varying intensity and in some cases the opportunity to titrate downwards as well.

Illicit Use
Hydromorphone appears on the street to an extent, with more than 99% sourced from patients selling prescriptions, armed robbery, and burglary of pharmacies. Slang terms for it include D, dilly, dillies, dill, k4, k1, k2, k3, k8, M8, Big D, Super 8, Hydro, M-80s, white triangle, moose, hospital heroin, drugstore heroin, shake & bake, peaches, and others. The equipotency of price to dosage ranks hydromorphone among the highest priced of all opioids for sale on the street. Both licit and illicit users as well as older pharmacists and doctors refer to hydromorphone tablets by their hydromorphone content in fractions of a grain (e.g. a "sixteenth" is a 4 mg tablet, an "eighth" is 8 mg, a "thirty-second" is 2 mg, 1 mg tablets are "sixty-fourths", the 3 mg tablet is a "three sixty-fourth" and long term Dilaudid users both licit and illicit as well as pharmacists may remember quarter-grain (16 mg) tablets back in the day.

Capsules of up to 36 mg hydromorphone are also available on the street. Despite this large dose, they are not highly sought after when there is a choice between them and the traditional 2, 4, and 8 milligram tablets. The capsules are large and brightly colored (yellow for 18 mg, red for 30 mg), and within they contain tiny beads which are maddeningly hard, which no amount of cooking will break apart. The only way to break them to a powder is by brute force, with a heavy mortar, stories are heard of coffee grinders. The beads are not like those found in many pharmaceuticals which melt or break apart easily, but are closer to those found in Kadian brand 100 mg morphine capsules. Although this prevents easy injection, it seems likely that the true intent of the manufacturer was to ensure the slow dissolution of a large dose of narcotics in the patients stomach.

The clandestine production of hydromorphone is an only moderately difficult proposition which calls for equipment and other tools readily available (although expensive in the case of Column VII catalysts like Platina Black or collodial platinum) and it is possible via catalytic hydrogenation of morphine or demethylation of hydrocodone. One sticking point: purified hydrocodone or starting quantities on the order of 3 grammes or more of morphine are required. The details for the former case are available in German patents from the middle 1930s op. cit. which show several methods of creating dihydromorphinone class semi-synthetics; some of the methods which do not require hydrogen gas have yields of upwards of 70 per cent.

The aforementioned increase in licit use has, with time, led to downward price pressure both from changes in the simple supply and demand equation that governs all commerce and the fact that the low bioavailability of hydromorphone as compared to oxycodone means that a given reseller's clientele will usually have a large contingent of non-needle-using customers who may have tried hydromorphone by mouth and been disappointed and who want oxycodone, hydrocodone, and to a lesser extent codeine and dihydrocodeine, therefore affecting the demand side of the equation as well.
 

Withdrawal
The short length of action of hydromorphone and other metabolic factors mean that the abstinence syndrome (withdrawal) is brief but intense; a heavy and/or long-term user of hydromorphone opting or otherwise forced to quit "cold turkey" can expect a withdrawal syndrome as intense as that of morphine but much more severe in that it is compressed into a spike which will peak in 14 to 21 hours and resolve in 36 to 72 hours, provided they were not taking other longer-acting opioids, or have abnormalities in drug metabolism and/or liver or kidney function. All of the effects of hydromorphone and its attendant withdrawal syndrome can be significantly lengthened by such factors; possible but less common is the opposite: some patients require oral doses of hydromorphone as frequently as every 90 minutes and the withdrawal syndrome would compress into an even more violent spike which can peak in as little as 9 hours.

 Brand names and dosage forms
Hydromorphone is known in various countries around the world by the trade names Hydal, Sophidone, Hydrostat, Hydromorfan, Hydromorphan, Laudicon, Hymorphan, Opidol, Palladone and others (Warning: The brand names are inconsistent from country to country.). An extended-release version of hydromorphone called Palladone was available for a short time in the United States before being voluntarily withdrawn from the market after an FDA advisory released in July 2005 warned of a high overdose potential when taken with alcohol; it is still available in the United Kingdom under the brand name Palladone SR as of March 2007, and in most other European countries. Another extended-release version called Hydromorph Contin, manufactured as controlled release capsules, continues to be produced and distributed in Canada by Purdue Pharma Inc. in Pickering, Ontario. In addition to Purdue-Frederick, other manufacturers of hydromorphone products include Ethex, Knoll, Abbott, Endo, Mallinkroft, Merck, Mundipharma, and Lannacher amongst others.

Side effects
Adverse effects of hydromorphone are similar to those of other opioid analgesics, such as morphine. The major hazards of hydromorphone include dose-related respiratory depression and sometimes circulatory depression.[6] More common side effects include light-headedness, dizziness, sedation, constipation, nausea, vomiting, and sweating.[6] Massive overdoses are rarely observed in opioid tolerant individuals, but when they occur they may lead to circulatory system collapse. A particular problem that may occur with hydromorphone is accidental administration instead of morphine due to a mix-up between the similar names, either at the time the prescription is written or when the drug is dispensed. This has led to several deaths and calls for hydromorphone to be distributed in distinctly different packaging to morphine to avoid confusion.[7][8] The effects of overdose can be exaggerated by dose dumping if the medication is taken with alcohol or benzodiazepines.[9]

A possible and likely side effect associated with hydromorphone is euphoria, achieved dually through a perceived effect from the transition of a state of pain to a state of pain-relief induced through opioids, or through direct stimulation of the μ opioid receptor (μ1 and μ2) [of which hydromorphone, related to the morphine molecule, is a primary μ agonist]. Although this can lead to addiction and reward-seeking behavior, it has been demonstrated that when opioids are taken for pain relief, patients are very unlikely to misuse the drug (see Opioids). Nevertheless, there is a certain risk of abuse and dependence among patients prescribed any opioid, including hydromorphone.[10] A question long debated in medicine has been whether or not addiction potential and analgesia are separable; the existence of drugs such as cyclazocine and other benzomorphans may point to the con side of the debate yet it is easy to understand why a drug which acts against all components of pain in the way that opioids would generate a seek orientation, morbid or not, in any organism under consideration, from fish to frogs to rats to monkeys to people.

How To Pass A Drug Urine Test For Hydromorphone.  Learn Detection Times and Cut Off Levels:

• How long the drugs will be detectable depends on which resource you consult.  We have provided a list of conservative Drug Detection Times provided by the manufactures of the drug tests.

• For the cutoff levels of commonly abused drugs and more about drug testing take a look at Drug Testing Cutoff Levels.