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Meperidine

Introduced as an analgesic in the 1930s, meperidine produces effects that are similar, but not identical, to morphine (shorter duration of action and reduced antitussive and antidiarrheal actions). Currently it is used for pre-anesthesia and the relief of moderate to severe pain, particularly in obstetrics and post-operative situations. Meperidine is available in tablets, syrups, and injectable forms under generic and brand name (Demerol®, Mepergan®, etc.) Schedule II preparations. Several analogues of meperidine have been clandestinely produced. During the clandestine synthesis of the analogue MPPP, a neurotoxic by-product (MPTP) was produced. A number of individuals who consumed the MPPP-MPTP preparation developed an irreversible Parkinsonian-like syndrome. It was later found that MPTP destroys the same neurons as those damaged in the Parkinsonian-like syndrome. It was later found that MPTP destroys the same neurons as those damaged in Parkinsons Disease.

External Links

  1. ^ "Lekopedia - Dolargan". jestemchory.pl. http://www.jestemchory.pl/lek.via?id=99824&str=19&l=d&r=h&VSID=4c69dc1b3a23b828e497dea2157f0263. Retrieved on 2006-08-01. 

  2. ^ Demerol RxList. Retrieved 19 Jun. 2006.

  3. ^ Kaiko, Robert F.; Kathleen M. Foley, Patricia Y. Grabinski, George Heidrich, Ada G. Rogers, Charles E. Inturrisi, Marcus M. Reidenberg (February 1983). "Central Nervous System Excitatory Effects of Meperidine in Cancer Patients". Annals of Neurology (Wiley Interscience) 13 (2): 180–185. doi:10.1002/ana.410130213. ISSN: 0364-5134. 

  4. ^ Donna Wong (2002-03-15). "Notes on Meperidine". Wong on Web Papers. Elsevier. http://www.mosbysdrugconsult.com/WOW/op024.html. Retrieved on 2007-04-13. 

  5. ^ a b Davis, Sharon (August 2004). "Use of pethidine for pain management in the emergency department: a position statement of the NSW Therapeutic Advisory Group" (PDF). New South Wales Therapeutic Advisory Group. http://www.clininfo.health.nsw.gov.au/nswtag/publications/posstats/Pethidinefinal.pdf. Retrieved on 2007-01-17. 

  6. ^ a b c d Latta, Kenneth S.; Brian Ginsberg, Robert L. Barkin (January/February 2002). "Meperidine: A Critical Review". American Journal of Therapeutics (Lippincott Williams & Wilkins) 9 (1): 53–68. doi:10.1097/00045391-200201000-00010. ISSN: 1075-2765. 

  7. ^ Wagner, Larry E., II; Michael Eaton, Salas S. Sabnis, Kevin J. Gingrich (November 1999). "Meperidine and Lidocaine Block of Recombinant Voltage-Dependent Na+ Channels: Evidence that Meperidine is a Local Anesthetic". Anesthesiology (Lippincott Williams & Wilkins) 91 (5): 1481–1490. doi:10.1097/00000542-199911000-00042. ISSN: 0003-3022. 

  8. ^ a b c Izenwasser, Sari; Amy Hauck Newman, Brian M. Cox, Jonathan L. Katz (January/February 1996). "The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter". European Journal of Pharmacology (Elsevier) 297 (1-2): 9–17. doi:10.1016/0014-2999(95)00696-6. ISSN: 0014-2999. 

  9. ^ Lomenzo, Stacey A.; Jill B. Rhoden, Sari Izzenwasser, Dean Wade, Theresa Kopajtic, Jonathan L. Katz, Mark L. Trudell (2005-03-05). "Synthesis and Biological Evaluation of Meperdine Analogs at Monoamine Transporters". Journal of Medicinal Chemistry (American Chemical Society) 48 (5): 1336–1343. doi:10.1021/jm0401614. ISSN: 0022-2623. 

  10. ^ a b c d "Demerol: Is It the Best Analgesic?" (PDF). Pennsylvania Patient Safety Reporting Service Patient Safety Advisory (Pennsylvania Patient Safety Authority) 3 (2). June 2006. http://www.psa.state.pa.us/psa/lib/psa/advisories/v3n2june2006/junevol_3_no_2_article_g_demerol.pdf. Retrieved on 2007-01-16. 

  11. ^ "In Brief". NPS Radar. National Prescribing Service. December 2005. http://www.npsradar.org.au/site.php?page=1&content=/npsradar/content/latestnews.html. Retrieved on 2007-01-17. 

  12. ^ Walker, Diana J.; James P. Zacny (June 1999). "Subjective, Psychomotor, and Physiological Effects of Cumulative Doses of Opioid µ Agonists in Healthy Volunteers". The Journal of Pharmacology and Experimental Therapeutics (American Society for Pharmacology and Experimental Therapeutics) 289 (3): 1454–1464. 

  13. ^ Norpethedine half-life. 2002. Australian prescriber[1]

  14. ^ Brody, Jane (February 27, 2007). "A Mix of Medicines That Can Be Lethal". New York Times. http://www.nytimes.com/2007/02/27/health/27brody.html?n=Top/News/Health/Diseases,%20Conditions,%20and%20Health%20Topics/Antidepressants. Retrieved on 2009-02-13. "The death of Libby Zion, an 18-year-old college student, in a New York hospital on March 5, 1984, led to a highly publicized court battle and created a cause célèbre over the lack of supervision of inexperienced and overworked young doctors. But only much later did experts zero in on the preventable disorder that apparently led to Ms. Zion’s death: a form of drug poisoning called serotonin syndrome." 

How To Pass A Drug Urine Test For Meperodine.  Learn Detection Times and Cut Off Levels:

  • How long the drugs will be detectable depends on which resource you consult.  We have provided a list of conservative Drug Detection Times provided by the manufactures of the drug tests.

  • For the cutoff levels of commonly abused drugs and more about drug testing take a look at Drug Testing Cutoff Levels.

 

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